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Use fecal calprotectin to distinguish IBD from IBS
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What to Do
Ask your doctor for a fecal calprotectin test if you have chronic digestive symptoms. This biomarker measures intestinal inflammation and reliably distinguishes inflammatory bowel disease (IBD) from irritable bowel syndrome (IBS).
Why It Works
Calprotectin is released by neutrophils during intestinal inflammation. Levels above 250 µg/g strongly suggest IBD (Crohn's or ulcerative colitis), while normal levels (< 50 µg/g) make IBD unlikely. Unlike commercial microbiome tests, this is a clinically validated, insurance-covered diagnostic tool with clear action thresholds.
Tips
- Covered by most insurance plans when ordered by a physician
- Results guide whether you need a colonoscopy or can pursue IBS management
- NSAIDs can temporarily elevate calprotectin — stop them before testing if possible
📅 Created: 2/9/2026, 5:07:38 AM 📌 research 🔧 None