Be aware of NSAID effects on gut lining

What to Do

Minimize regular use of NSAIDs (ibuprofen, naproxen, aspirin) and never take them on an empty stomach. If you need frequent pain relief, discuss alternatives with your doctor.

Why It Works

NSAIDs inhibit prostaglandin production, which is essential for maintaining the protective mucus layer in the stomach and intestines. Regular use causes small intestinal damage in 65-70% of users within 2 weeks (visible on capsule endoscopy). This increases intestinal permeability and shifts the microbiome toward pro-inflammatory species.

Tips

• Always take NSAIDs with food to reduce direct mucosal contact
• Zinc carnosine (75mg) taken alongside NSAIDs reduces gut damage by up to 75%
• Acetaminophen (Tylenol) doesn't cause GI damage but has liver concerns
• Topical NSAIDs (creams, patches) bypass the gut entirely for localized pain