Understand the runner's high — it's real neurochemistry

What to Do

Know that the runner's high is a scientifically documented phenomenon driven by your endocannabinoid system, not endorphins as previously believed. It typically kicks in during sustained effort at 70-85% of max heart rate.

Why It Works

Research shows endorphins are too large to cross the blood-brain barrier. Instead, running releases anandamide and 2-AG (endocannabinoids) that produce euphoria, reduced anxiety, and pain relief. A study found runners given an opioid blocker still experienced the high, confirming endocannabinoids drive the effect. Regular runners experience stronger mood increases than occasional runners.

Tips

• The runner's high isn't guaranteed on every run — it tends to occur during sustained moderate-hard effort
• Women show higher endocannabinoid concentration increases than men in studies
• Even without the "high," most runs produce measurable mood improvement
• The mental health benefits of running are among the most robust findings in exercise science