Do probiotic supplements actually work?

Do not automatically take a multi-strain probiotic supplement after finishing antibiotics. The Weizmann Institute research found that standard probiotics can actually delay microbiome restoration compared to doing nothing.

If refrigeration or travel is a concern, consider spore-forming Bacillus species (B. subtilis, B. coagulans, B. clausii). These survive stomach acid, heat, and storage without refrigeration.

Set realistic expectations for probiotic supplements. Landmark research from the Weizmann Institute showed that most probiotics pass through the gut without colonizing, and some people are natural "resisters" who expel them entirely.

Ignore marketing that emphasizes "50 billion CFU" or "100 billion CFU" as proof of superiority. Most clinical studies use 1-20 billion CFU. Choose products based on evidence for specific strains, not raw CFU numbers.

Take B. infantis 35624 (sold as Align) daily if you have IBS symptoms. Follow the product dosing instructions (typically 1 capsule daily).

Take Saccharomyces boulardii (brand name Florastor) during antibiotic courses or before/during travel to high-risk destinations. Standard dose is 250-500 mg twice daily.

Choose probiotic supplements based on the specific strain studied for your condition, not by brand name or CFU count. Benefits demonstrated for one strain cannot be assumed for another, even within the same species.